Background: The increasing complexity of contemporary challenges requires research approaches that effectively integrate scientific knowledge, technological innovation, and societal needs. Integrative multidisciplinary research has emerged as a critical framework for bridging these domains through systematic methodological approaches.

Objective: This study examines integrative approaches in multidisciplinary research, analyzing frameworks, methodologies, and applications that successfully connect science, technology, and society to address complex real-world problems.

Methods: A comprehensive literature review was conducted examining integrative research methodologies, Science-Technology-Society frameworks, sociotechnical systems approaches, and transdisciplinary case studies. Sources included peer-reviewed articles, methodological papers, case studies, and institutional reports spanning 2003-2025.

Results: Key integrative approaches include Science-Technology-Society (STS) integration, sociotechnical systems design, transdisciplinary case studies, integrative mixed methods, and knowledge co-production. Successful applications demonstrate effectiveness in social innovation, sustainable technology development, and community-based solutions. However, challenges persist including methodological complexity, institutional barriers, and coordination difficulties.

Conclusion: Integrative multidisciplinary research provides essential frameworks for bridging science, technology, and society, generating transformative outcomes through systematic integration of diverse knowledge domains. Success requires continued development of methodological frameworks and institutional support structures