The safe disposal of unused and expired medications is a critical public health and environmental concern, a growing issue that has been linked to drug misuse, accidental poisoning, and environmental contamination. This review paper synthesizes existing literature on the effectiveness and policy implications of community-based drug take-back programs. By examining a range of case studies and policy analyses, this paper evaluates the logistical models, public participation rates, and overall impact of these initiatives on reducing drug diversion and environmental hazards. Furthermore, it explores the legislative and funding frameworks that either support or hinder the widespread implementation of these programs. The review concludes that while community-based take-back programs are effective in achieving their primary goals, their sustainability and scalability are heavily reliant on robust, supportive policies and multi-stakeholder collaboration. This paper provides recommendations for policymakers and public health officials aimed at strengthening these programs to maximize their effectiveness.