The paper looked at global warming and the environmental challenges and the need for the enforcement of a sustainable education regime in Nigeria to contain global warming. The author identified and discussed factors responsible for global warming. Pollutions emanating from the release of fumes and carbon dioxide from heavy duty machines from industries, environmental degradation occasioned by the crude method of oil exploration in many third world and developing countries, and the crude method of agricultural practice in the developing countries, among others, were identified as the major sources and causes of environmental pollution. Consequently, the paper also observed that the Ozone layer has been seriously depleted by these pollutions mentioned in the paper leading to green- house effect on the environment, thereby increasing the incidence of heat waves on the globe with its associated health hazards on humans and other living organisms in their natural habitat. To drive his point home, the author anchored his argument on the world system theory, by Emmanuel Wellestine. The world system theory as a theoretical framework, emphasized the interlink-age of global activities and the interdependence of various parts of the globe, which he identified as the core, the periphery and the semi-periphery. The theory maintains that any negative action on the environment emanating from any part of the globe will invariably affect other parts of the globe without an exception. Given the environmental challenges associated with global warming, the author emphasized the need for a sustainable environmental regime through education to curtail environmental pollution and degradation thereby reducing global warming.However, the author observe that outdated laws, corruption, poor funding and ignorance among others are the major challenges to the enforcement of sustainable environmental regime in Nigeria. Based on the identified challenges, the author recommends the review and the enactment of relevant environmental laws, the recruitment of environmental friendly personnel, proper funding of environmental regimes and mass orientation through education as panacea for sustainable environmental safety practices in Nigeria.