Descriptive survey research design was adopted for this study. The population of the study comprised, student-athletes from Nigerian Universities. The sample size of the study was One hundred and twenty (120) respondents selected, through a simple random sampling technique. Two research questions were raised to guide the conduct of the study. Self-structured research instruments by the researchers were used to obtain data for the study, titled “Questionnaire on Investigative Study on Psycho-Social Determinants of Drug Addictiveness among Nigerian Universities Athletes (QISPDDANUA)”. It was test-retested on the four Likert rating scale of Strongly Agreed (SA), Agreed (A), Disagreed (D), and Strongly Disagreed (SD), rated on 4, 3, 2 and 1 respectively, complemented with qualitative data obtained through FGD (Focus Group Discussions). The research instruments were validated by two experts in Measurement and Evaluation while its reliability was determined using the test-retest method at two weeks interval. The reliability coefficient established was 0.87. Descriptive statistics (simple percentages, frequency counts and mean) were used to analyze the data. The quantitative data that were generated with the questionnaire were collected, transcribed and analyzed. Based on the results, it was found that drug addictiveness negatively affects the performance of Nigerian University student-athletes not significantly. Also, there is a psycho-social motivation in athletes' performance, which could be enhanced through awareness and counseling. Recommendations were therefore, made based on the conclusions that NUGA should device method of discovering athletes under the influence of drug substances. Also, severe punishment should be given to athletes found to be taken drug,and so on.